Process for the production of stable, sterilizable, complex auro-sodiumthiosulphate solutions



- Novo 8, 1%27.

LUDWIG BENDA, F MAINKUR, NEAR FRANKFORT-ON-THE-MAIN, GERMANY, AS-

SIGNOB TO I. G. FARBENINDUSTRIE AKTIENGESELLSCHAFT, A CORPORATION OFGERMANY.

PROCESS FOR THE PRODUCTION OF STABLE, STERILIZABLE, COMPLEXAURO-SOD'IUM- THIOSULPHATE SOLUTIONS.

No Drawing. Application filed November 30, 1925, Serial No. 72,407, andin Germany January 27, 1925.

The complex compound Na Au(S O 21-1 0 described by Fordos & Gli's (Ann.de Chim. et de Phys. serie 3 vol. 13(1845) page 394 and following)decomposes when heated 5 in the solid state as well as in solution, so

that sterilization as required for application in the form of injectionsis not feasible.

I have found that by the addition of sodium thiosulphate solutions maybe prepared which are stable and sterilizable and which,

in contrast with the gold preparations hith- Example 1.

10 g. Na Au(S O .2aq are finely mixed with 5 g. sodium thiosulphate,this mixture dissolved 1n 1000 cc. distilled water, filled in ampoulesand sterilized for one hour at 100 C. The solution remains colorless andas clear as water, whereas a solution of Na Au (-S O .2aq treated in thesame way, is colored dark.

Emamle Q.

10 g. Na Au(S O .2aq are dissolved at ordinary temperature in 500 cc.distilled water, adding a solution of 5 g. sodium thiosulphate in 500cc. distilled water, filling in ampoules and sterilizing for one hour at100 C. The solution remains clear and unchanged, whereas a test portionwithout the addition of sodium thiosulphate is decomposed (precipitationof a brownish-black sediment after a passing reddish-violet coloration).

Having now particularly described and ascertained the nature of my saidinvention and inwhat manner the same is to be performed, I declare thatwhat I claim is:

1. A process for the production of stable, sterilizable, complexauro-sodium thiosul- V phate solutions by mixing complex auro-sodiumthiosulphate with sodium thiosulphate as solid substances and thendissolving.

2. A roces's for the production of stable, steriliza le, complexauro-sodium, thiosulphate solutions by mixing complex auro sodiumthiosulphate and sodium thiosulphate in solutions.

3. As new products stable and sterilizable, complex auro-sodiumthiosulphate solutions, being colorless, clear solutions which alsoremain invariabl clear on sterilizing.

In witness whereof I have hereunto signed my name this 12th da ofNovember, 1925.

UDWIG' BENDA.

